Using a urinary immunoassay to measure aflatoxin metabolites, we examined the associations between exposure to aflatoxin, chronic infection with the hepatitis-B virus (HBV) and background rates of hepatocellular carcinoma (HCC) mortality in a cross-sectional survey of 250 residents from 8 areas of Taiwan with a 4-fold variation in age-adjusted HCC mortality.
Specimens of fasting blood and overnight urines were used to determine HBV carrier status and excretion of aflatoxin in the subjects surveyed.
While the prevalence of hepatitis-B virus carriers showed moderate variability, there was a 500-fold range in urinary aflatoxin levels.
Mean log-transformed levels of aflatoxin metabolites were similar in males and females and in HBV carriers and non-carriers.
Mots-clés Pascal : Hépatome, Epithélioma, Foie, Hépatite virale B, Virose, Infection, Aflatoxine, Urine, Facteur risque, Epidémiologie, Taiwan, Asie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Liver cell carcinoma, Carcinoma, Liver, Viral hepatitis B, Viral disease, Infection, Aflatoxin, Urine, Risk factor, Epidemiology, Taiwan, Asia, Human, Digestive diseases, Hepatic disease, Malignant tumor
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0361709
Code Inist : 002B13C01. Création : 199406.