Chromatographic determination of volatile solvents and their metabolites in urine for monitoring occupational exposure.
The determination of volatile solvents and their metabolites in biological materials such as expired air, blood or urine allows the estimation of the degree of exposure of these chemicals.
Chromatographic methods are now universally employed for this purpose and numerous analytical procedures are available for the determination of the most commonly used volatile solvents and their metabolites in urine.
GC methods appear well adapted to the determination of the parent volatile solvents in blood and urine and may be used for the determination of their urinary metabolites, but these methods often require several prechromatographic steps.
However, HPLC is becoming a powerful tool for the acourate and easy determination of urinary metabolites of volatile solvents, considering its decisive advantages for routine monitoring.
Mots-clés Pascal : Solvant organique, Analyse quantitative, Métabolisme, Urine, Liquide biologique, Surveillance, Exposition professionnelle, Méthode étude, Composé volatil, Chromatographie phase gazeuse, Chromatographie HPLC, Chromatographie couche mince, Homme
Mots-clés Pascal anglais : Organic solvent, Quantitative analysis, Metabolism, Urine, Biological fluid, Surveillance, Occupational exposure, Investigation method, Volatile compound, Gas chromatography, HPLC chromatography, Thin layer chromatography, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0293272
Code Inist : 002B03L04. Création : 199406.