This review considers the value of the observation that Legionnaires' disease varies geographically.
Estimates of disease incidence, derived from case registers and from studies measuring the proportion of cases of pneumonia which are Legionnaires' disease, and of the prevalence of the population with antibody, show that there is geographical variation in disease frequency.
Much, but not all, of this variation is artefact due to differences in definitions, diagnostic methods, surveillance systems and data presentation.
Some of the variation is attributed to publication bias, e.g. in 10 small studies (<100 patients) 13.2% of pneumonia patients had Legionnaires'disease but in five large studies (>=500 patients) the figure was 3.6%.
Mots-clés Pascal : Maladie des légionnaires, Légionellose, Bactériose, Infection, Variation géographique, Epidémiologie, Homme, Méthodologie, Article synthèse, Appareil respiratoire pathologie, Poumon pathologie, Pneumonie, Biais
Mots-clés Pascal anglais : Legionnaires disease, Legionellosis, Bacteriosis, Infection, Geographical variation, Epidemiology, Human, Methodology, Review, Respiratory disease, Lung disease, Pneumonia, Bias
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0148674
Code Inist : 002B05B02E. Création : 199406.