logo BDSP

Base documentaire

  1. Safety, tolerability and immunogenicity of a formalin-inactivated hepatitis A vaccine (VASTA) in rural Kentucky children.

    Article - En anglais

    This study evaluated the immunogenicity and safetyJtolerability profile of an investigational formalin-inactivated hepatitis A virus vaccine (VAQTA; Merck Research Laboratories) in 160 seronegative healthy children, 4 to 1 2 years old.

    The vaccine was derived from virus grown in infected MRC-Q cells in either roller bottles or Nunc cell factories (Nunc, Denmark).

    Subjects were vaccinated intramuscularly in a two dose regimen initially and at 24 weeks:

    • Group A (n=50) with a 12-unit dose from a roller bottle lot;

    • Group B (n=50) with a 25-unit dose from another roller bottle lot;

    • and Group C (n=50) with a 25-unit dose from a unc cell lot.

    Mots-clés Pascal : Hépatite virale A, Virose, Infection, Toxicité, Vaccination, Voie intramusculaire, Anticorps, Immunité humorale, Immunogénicité, Vaccin, Kentucky, Etats Unis, Amérique du Nord, Amérique, Enfant, Homme, Immunoprophylaxie, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Toxicity, Vaccination, Intramuscular administration, Antibody, Humoral immunity, Immunogenicity, Vaccine, Kentucky, United States, North America, America, Child, Human, Immunoprophylaxis, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0120274

    Code Inist : 002B05C02G. Création : 199406.