A cohort study of cystic fibrosis and malignancy.
A cohort of 412 patients first attending a cystic fibrosis (CF) clinic between 1961 and 1989 were followed up to 30 June 1989.
The number of malignancies observed in the cohort was compared with the number expected based on the age, sex and calendar-year-specific cancer registration rates for England and Wales.
Four CF patients were diagnosed as having malignancies before 30 June 1989.
The tumours were: adenocarcinoma of the terminal ileum; adenocarcinoma of the pancreas, testicular teratoma, and B-cell lymphoma.
This compares with 0.89 malignancies expected on the basis of rates in England and Wales.
(Standardised Registration Ratio=452; 95% confidence interval 122-1150, P=0.03).
Mots-clés Pascal : Mucoviscidose, Incidence, Etude cohorte, Association, Epidémiologie, Royaume Uni, Europe, Homme, Appareil respiratoire pathologie, Appareil digestif pathologie, Pancréas pathologie, Maladie héréditaire
Mots-clés Pascal anglais : Mucoviscidosis, Incidence, Cohort study, Association, Epidemiology, United Kingdom, Europe, Human, Respiratory disease, Digestive diseases, Pancreatic disease, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0110298
Code Inist : 002B04B. Création : 199406.