The loss of CD4 lymphocytes is known to be an important component of human immunodeficiency virus type 1 (HIV-1) pathogenesis.
It remains unclear, however, whether the importance of the CD4 lymphocyte count is such that individuals who have been infected for widely different lengths of time, but for whom the CD4 lymphocyte count is the same, have the same risk of developing acquired immunodeficiency syndrome (AIDS).
The authors directly addressed this question for 111 HIV-1-infected hemophiliacs who had been followed for up to 12 years from seroconversion and for whom a median of 16 CD4 lymphocyte counts had been made.
Thirty-eight patients had developed AIDS by January 1, 1992.
As of August 1, 1985, the time from sero-conversion to AIDS ranged from 3 weeks to almost 6 years.
Mots-clés Pascal : SIDA, Virose, Infection, Immunopathologie, Hémopathie, Epidémiologie, Séropositivité, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Lymphocyte, Numération, Etude transversale, Royaume Uni, Europe, Hémophilie, Coagulopathie, Maladie héréditaire, Antigène CD4
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Immunopathology, Hemopathy, Epidemiology, Seropositivity, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Lymphocyte, Numeration, Cross sectional study, United Kingdom, Europe, Hemophilia, Coagulopathy, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0108512
Code Inist : 002B06D01. Création : 199406.