Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer.
The authors recently published data from a prospective cohort study of postmenopausal women (N Engl J Med 1992;326: 1323-9) which suggested that a high waist/hip ratio was associated with a significantly increased risk of breast cancer in women with a positive family history of breast cancer.
Since families with aggregations of breast and ovarian cancer demonstrate more consistent genetic linkage to markers on chromosome 17q than do families with breast cancer alone, the authors performed additional analyses to examine whether the previously observed associations with waist/hip ratio differed when family history of breast cancer was partitioned according to whether or not ovarian cancer was also present in a close relative.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Glande mammaire pathologie, Postménopause, Homme, Femelle, Obésité, Ovaire, Appareil génital femelle pathologie, Facteur risque, Prospective, Epidémiologie, Histoire familiale, Etat nutritionnel, Trouble nutrition
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Mammary gland diseases, Postmenopause, Human, Female, Obesity, Ovary, Female genital diseases, Risk factor, Prospective, Epidemiology, Family story, Nutritional status, Nutrition disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0108506
Code Inist : 002B20E02. Création : 199406.