About 25% of blood donors who test positive for antibody to hepatitis B core antigen (anti-HBc) have no other positive hepatitis B serologic results.
Because of the potential importance and diagnostic uncertainty of this test result, we studied its significance by assessing the serologic response to hepatitis B vaccine in donors with an isolated anti-HBc pattern.
Specimens from 300 blood donors that were positive for anti-HBc by enzyme immunoassay were tested for anti-HBc by radioimmunoassay and for antibody to hepatitis B surface antigen (anti-HBs).
A subgroup of 37 were further studied after administration of hepatitis B vaccine and compared with 34 similarly vaccinated ageand sex-matched seronegative controls.
Mots-clés Pascal : Exploration, Homme, Anticorps, Exploration immunologique, Sang, Donneur, Virus hépatite B, Hepadnaviridae, Virus
Mots-clés Pascal anglais : Exploration, Human, Antibody, Immunological investigation, Blood, Donor, Hepatitis B virus, Hepadnaviridae, Virus
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0102838
Code Inist : 002B27D01. Création : 199406.