The hypothesis that adult infection with the hepatitis B virus in the United States leads to a carrier state with a high risk of primary liver cancer was tested in two ways: (a) a cohort mortality study of U.S. Army veterans given yellow fever vaccine contaminated with hepatitis B virus in 1942 and controls and (b) a case-control study comparing veterans with hepatocellular carcinoma in Veterans Affairs hospitals with matched controls with respect to receipt of contaminated vaccine in 1942.
Three groups totaling 69,988 men were the subjects of the cohort study: group 1 comprised men hospitalized with hepatitis in 1942, group 2 comprised men subclinically infected in 1942 and group 3 comprised controls who entered service after the contaminated vaccine was discontinued.
Mots-clés Pascal : Hépatite virale B, Virose, Infection, Epidémie, Epidémiologie, Transmission, Mode transmission, Voie orale, Etats Unis, Amérique du Nord, Amérique, Pronostic, Facteur risque, Mortalité, Armée, Hépatome, Homme, Foie pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Epidemic, Epidemiology, Transmission, Transmission mode, Oral administration, United States, North America, America, Prognosis, Risk factor, Mortality, Army, Liver cell carcinoma, Human, Hepatic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0088276
Code Inist : 002B05C02G. Création : 199406.