Several years ago it was reported that rare HRAS1 VNTR alleles occurred more frequently in U.S. Caucasian cancer patients than in unaffected controls.
Such an association, in theory, could be caused by undetected population heterogeneity.
Also, in a study clearly relevant to this issue, it was recently reported that significant deviations from Hardy-Weinberg equilibrium exist at this locus in a sample of U.S. Caucasians.
These considerations motivate our population genetic analysis of the HRAS1 locus.
From published studies of the HRAS1 VNTR locus, which classified alleles into types, we found only small differences in the allele frequency distributions of samples from various European nations, although there were larger differences among ethnic groups (African American, Caucasian, and Oriental).
Mots-clés Pascal : Génétique population, Homme, DNA satellite, Fréquence génique, Polymorphisme, Nationalité, Tumeur maligne, Synthèse bibliographique, Risque, Métaanalyse, Génétique, Epidémiologie, Minisatellite, Locus HRSA1
Mots-clés Pascal anglais : Population genetics, Human, Satellite DNA, Gene frequency, Polymorphism, Nationality, Malignant tumor, Bibliographic survey, Risk, Metaanalysis, Genetics, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0074094
Code Inist : 002A07E03. Création : 199406.