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  1. Sufficient conditions for treatment responders to have longer survival than non-responders.

    Article - En anglais

    In cancer clinical trials, tumor response, defined in terms of predetermined relative decrease in tumor size, and overall survival are often used to evaluate treatment efficacy.

    Investigators often attempt to demonstrate a positive relationship between the two measures by comparing the survival of the responders to that of the non-responders.

    The biasedness of this comparison is explored mathematically.

    Sufficient conditions on the hazard functions to response and dying without responding are given so that the responders have stochastically longer survival than the non-responders.

    The conditions contain no restrictions on how response status might alter the subsequent death hazard.

    Examples are given where achieving a response has no or adverse impact on survival and yet responders appear to have longer survival.

    Mots-clés Pascal : Tumeur maligne, Efficacité traitement, Homme, Survie, Taille, Corrélation, Essai clinique, Pronostic, Analyse risque, Analyse statistique

    Mots-clés Pascal anglais : Malignant tumor, Treatment efficiency, Human, Survival, Size, Correlation, Clinical trial, Prognosis, Risk analysis, Statistical analysis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0066895

    Code Inist : 002B28F. Création : 199406.