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  1. Role of human cytochrome P-450s in risk assessment and susceptibility to environmentally based disease.

    Article, Congrès - En anglais

    Hanford symposium on health and the environment. Richland WA (USA), 1992/10/20.

    Cytochromes P-450 (P-450s) are a large group of heme-containing proteins that carry out oxidation of numerous chemicals.

    In mammals, a limited number of P-450s are involved in metabolic pathways of steroid synthesis, while most of these enzymes are involved in metabolism of foreign compounds.

    The principal beneficial function of P-450s is to convert chemicals into derivatives that can be easily eliminated from the body.

    This generally occurs through P-450-mediated oxidations of hydrophobic substances followed by conjugation reactions.

    For many foreign compounds, P-450 metabolism results in production of « activated » metabolites that can cause cell death and gene mutations.

    Mots-clés Pascal : Cytochrome P450, Carcinogène, Marqueur génétique, Détoxication, Composé chimique, Polluant, Environnement, Prédiction, Méthode étude, Toxicité, Homme, Evaluation, Risque, Sensibilité résistance, Comparaison interspécifique, In vitro, Toxicogénétique, Comparaison intraindividuelle, Expression génique, Isozyme, Relation métabolisme toxicité

    Mots-clés Pascal anglais : Cytochrome P450, Carcinogen, Genetic marker, Detoxication, Chemical compound, Pollutant, Environment, Prediction, Investigation method, Toxicity, Human, Evaluation, Risk, Sensitivity resistance, Interspecific comparison, In vitro, Toxicogenetics, Intraindividual comparison, Gene expression, Isozyme, Metabolism toxicity relation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0063771

    Code Inist : 002B03M01. Création : 199406.