The impact of age on risk of adverse drug reactions to digoxin.
To assess the association of age and other potential risk factors with digoxin toxicity, adverse drug reactions to digoxin (ADRDIG) were studied in all patients (n=1338) on digoxin therapy consecutively admitted to 41 clinical wards throughout Italy during 4 months in 1988.
At the time of admission, 28 patients (2.1%) had evidence of ADRDIG.
In multivariate logistic regression analysis, significant associations with ADRDIG were found for age >=80 years compared to age 65-79 years (OR=2.75, 95% CI=1.17-6.45), daily digoxin dosage of >=0.25 mg (OR=2.51, 95% CI=1.16-5.47), serum creatinine >=120 mumol/L (OR=3.75, 95% CI=1.69-8.32), and for treatment with amiodarone, propafenone, quinidine or verapamil (OR=2.60, 95% CI=1.07.6.30).
Mots-clés Pascal : Pharmacovigilance, Epidémiologie, Vieillard, Homme, Digoxine, Cardiotonique, Digitalique, Toxicité, Age, Italie, Europe, Glycoside
Mots-clés Pascal anglais : Drug monitoring, Epidemiology, Elderly, Human, Cardiotonic agent, Digitalis drug, Toxicity, Age, Italy, Europe, Glycoside
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0058643
Code Inist : 002B02U08. Création : 199406.