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  1. The impact of age on risk of adverse drug reactions to digoxin.

    Article - En anglais

    To assess the association of age and other potential risk factors with digoxin toxicity, adverse drug reactions to digoxin (ADRDIG) were studied in all patients (n=1338) on digoxin therapy consecutively admitted to 41 clinical wards throughout Italy during 4 months in 1988.

    At the time of admission, 28 patients (2.1%) had evidence of ADRDIG.

    In multivariate logistic regression analysis, significant associations with ADRDIG were found for age >=80 years compared to age 65-79 years (OR=2.75, 95% CI=1.17-6.45), daily digoxin dosage of >=0.25 mg (OR=2.51, 95% CI=1.16-5.47), serum creatinine >=120 mumol/L (OR=3.75, 95% CI=1.69-8.32), and for treatment with amiodarone, propafenone, quinidine or verapamil (OR=2.60, 95% CI=

    Mots-clés Pascal : Pharmacovigilance, Epidémiologie, Vieillard, Homme, Digoxine, Cardiotonique, Digitalique, Toxicité, Age, Italie, Europe, Glycoside

    Mots-clés Pascal anglais : Drug monitoring, Epidemiology, Elderly, Human, Cardiotonic agent, Digitalis drug, Toxicity, Age, Italy, Europe, Glycoside

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0058643

    Code Inist : 002B02U08. Création : 199406.