To determine the validity of ultrasonic nebulization of distilled water (UNDW, « fog ») in comparison with methacholine challenge, in the assessment of toluene diisocyanate (TDI) asthma, we evaluated 75 subjects exposed to TDI with work-related respiratory symptoms.
Subjects were submitted to bronchial challenge with methacholine at first, thereafter to UNDW inbalation and to specific challenge with TDI.
The diagnosis of TDI-asthma was made in 30 of 75 patients (40 percent) who developed a broncboconstrictive response to the specific challenge (reactors).
Sensitivity and specificity of UNDW alone, methacholine alone, and of the combination of the two tests were determined with the results of the specific challenge with TDI as the « gold standard ».
Mots-clés Pascal : Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Médecine travail, Exposition professionnelle, Exploration, Homme, Epreuve pharmacologique, Test respiratoire, Asthme, Brouillard, Ultrason, Réponse, Bronche, Toluène diisocyanate, Méthacholine
Mots-clés Pascal anglais : Respiratory disease, Obstructive pulmonary disease, Occupational medicine, Occupational exposure, Exploration, Human, Pharmacologic test, Breath test, Asthma, Fog, Ultrasound, Response, Bronchus
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0057362
Code Inist : 002B11B. Création : 199406.