Selenium has been suggested to be anticarcinogenic and to play a role in the cellular defense against oxidative stress.
The association between toenail selenium (a marker of long-term selenium status) and lung cancer was investigated in a cohort study of diet and cancer that started in 1986 among 120,852 Dutch men and women aged 55-69 years.
After 3.3 years of follow-up, 550 incident cases of lung carcinoma were detected.
Toenail selenium data were available for 370 lung cancer cases and 2459 members of a randomly selected subcohort.
The rate ratio of lung cancer for subjects in the highest compared to the lowest quintile of toenail selenium, after controlling for age, gender, smoking, and education, was 0.50 (95% confidence interval, 0.30-0.81), with a significant inverse trend across quintiles (P=0.006).
Mots-clés Pascal : Sélénium, Anticarcinogène, Dosage, Ongle, Facteur risque, Tumeur maligne, Bronchopulmonaire, Etude cohorte, Homme, Epidémiologie, Etude longitudinale, Oligoélément, Pays Bas, Europe, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Selenium, Anticarcinogen, Assay, Nail(anatomy), Risk factor, Malignant tumor, Bronchopulmonary, Cohort study, Human, Epidemiology, Follow up study, Oligoelement, Netherlands, Europe, Respiratory disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0056259
Code Inist : 002B11A. Création : 199406.