Levodopa therapy and survival in idiopathic Parkinson's disease : Olmsted County project.
We studied survival in all Olmsted County Parkinson's disease (PD) patients seen at the Mayo Clinic from 1964 to 1978, attempting to answer two questions: (1) What effect does levodopa have on survival in PD? and (2) Does the timing of levodopa administration influence survival?
We chose this period because it allowed us to study patient records with a spectrum of disease durations before levodopa treatment; in many patients, the treatment delay was exclusively due to levodopa being unavailable prior to 1969.
Mortality of the entire PD cohort (N=179; 61% levodopa-treated) was greater than that of the general population.
(matched chronologically, geographically, and by age and gender).
Mots-clés Pascal : Parkinson maladie, Homme, Chimiothérapie, Traitement, Lévodopa, Antiparkinsonien, Survie, Epidémiologie, Canada, Amérique du Nord, Amérique, Etude cohorte, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative
Mots-clés Pascal anglais : Parkinson disease, Human, Chemotherapy, Treatment, Levodopa, Antiparkinson agent, Survival, Epidemiology, Canada, North America, America, Cohort study, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0047415
Code Inist : 002B02B06. Création : 199406.