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  1. Trauma and multiple sclerosis : a population-based cohort study from Olmsted County, Minnesota.

    Article - En anglais

    Utilizing the Olmsted County, Minnesota, population-based records-linkage resource at Mayo Clinic, we identified an incidence and a prevalence cohort with multiple sclerosis (MS), a head injury cohort, and a lumbar disk surgery cohort to evaluate the association between mechanical trauma and MS onset or exacerbation.

    The MS cohorts consisted of 225 incidence cases (1905 to 1991) and 164 prevalence cases (December 1, 1991) of definite MS in the population of Olmsted County.

    We assessed the effect of mechanical trauma in the form of spinal injury or extremity fracture with regard to precipitation of MS or exacerbation of an existing neurologic deficit.

    Fifty-four episodes of trauma, as defined, occurred among 39 MS prevalence cases; most occurred 10 years or more after the onset of disease and were associated with existing MS-related disability.

    Mots-clés Pascal : Sclérose en plaque, Homme, Analyse corrélation, Chirurgie orthopédique, Rachis lombaire, Rachis pathologie, Système ostéoarticulaire pathologie, Incidence, Prévalence, Traumatisme, Crânioencéphalique, Epidémiologie, Minnesota, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Maladie inflammatoire, Encéphale pathologie

    Mots-clés Pascal anglais : Multiple sclerosis, Human, Correlation analysis, Orthopedic surgery, Lumbar spine, Disease of the spine, Diseases of the osteoarticular system, Incidence, Prevalence, Trauma, Craniocerebral, Epidemiology, Minnesota, United States, North America, America, Nervous system diseases, Central nervous system disease, Inflammatory disease, Cerebral disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0047408

    Code Inist : 002B17F. Création : 199406.