Differences in time from HIV seroconversion to CD4+ lymphocyte end-points and AIDS in cohorts of homosexual men.
To evaluate the decline in CD4+ counts in relation to the incidence of AIDS in different cohorts of homosexual men and to quantify possible consequences of laboratory variation in CD4+ measurement.
Our study includes 403 men with well documented dates of HIV seroconversion originating from five cohort studies among homosexual men.
Differences in time from HIV seroconversion to the first CD4+ count dropping <500 or 200x106/l and to AIDS were evaluated using Kaplan-Meier survival analyses.
We found considerable differences between cohorts in CD4+ depletion, but not in the incidence of AIDS (1987 definition).
Mots-clés Pascal : Homosexualité, SIDA, Virose, Infection, Maladie sexuellement transmissible, Mâle, Lymphocyte T, Homme, Hémogramme, Courbe survie, Incidence, Evolution, Epidémiologie, Pays Bas, Europe, Hémopathie, Immunopathologie, Antigène CD4, Séroconversion
Mots-clés Pascal anglais : Homosexuality, AIDS, Viral disease, Infection, Sexually transmitted disease, Male, T-Lymphocyte, Human, Blood cell count, Survival curve, Incidence, Evolution, Epidemiology, Netherlands, Europe, Hemopathy, Immunopathology, Seroconversion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0039570
Code Inist : 002B06D01. Création : 199406.