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  1. Differences in time from HIV seroconversion to CD4+ lymphocyte end-points and AIDS in cohorts of homosexual men.

    Article - En anglais

    Objective

    To evaluate the decline in CD4+ counts in relation to the incidence of AIDS in different cohorts of homosexual men and to quantify possible consequences of laboratory variation in CD4+ measurement.

    Methods

    Our study includes 403 men with well documented dates of HIV seroconversion originating from five cohort studies among homosexual men.

    Differences in time from HIV seroconversion to the first CD4+ count dropping <500 or 200x106/l and to AIDS were evaluated using Kaplan-Meier survival analyses.

    Results

    We found considerable differences between cohorts in CD4+ depletion, but not in the incidence of AIDS (1987 definition).

    Mots-clés Pascal : Homosexualité, SIDA, Virose, Infection, Maladie sexuellement transmissible, Mâle, Lymphocyte T, Homme, Hémogramme, Courbe survie, Incidence, Evolution, Epidémiologie, Pays Bas, Europe, Hémopathie, Immunopathologie, Antigène CD4, Séroconversion

    Mots-clés Pascal anglais : Homosexuality, AIDS, Viral disease, Infection, Sexually transmitted disease, Male, T-Lymphocyte, Human, Blood cell count, Survival curve, Incidence, Evolution, Epidemiology, Netherlands, Europe, Hemopathy, Immunopathology, Seroconversion

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0039570

    Code Inist : 002B06D01. Création : 199406.