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  1. Subclinical infection with Mycobacterium leprae : a problem for leprosy control strategies.

    Article - En anglais

    Tests for the serodiagnosis of leprosy, including those based on phenolic glycolipid-I (PGL-I), have shown poor specificity for leprosy in studies of endemic communities, despite initially promising results in studies of selected patients.

    During a 5 years follow-up study of a hyperendemic community in Papua New Guinea, a marked reduction in numbers of seropositive children and an increase in age of those seropositive followed introduction of multi-drug therapy.

    This was accompanied by a reduced case detection rate and a shift to paucibacillary disease in new cases, consistent with a reduction in transmission.

    Only a minority of persistently seropositive persons developed leprosy.

    Mots-clés Pascal : Lèpre, Mycobactériose, Bactériose, Infection, Asymptomatique, Etude longitudinale, Sérologie, Diagnostic, Anticorps, Mycobacterium leprae, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Phénols, Glycolipide, Endémie, Dépistage, Antilépreux, Antibactérien, Epidémiologie, Association médicamenteuse, Papouasie Nouvelle Guinée, Mélanésie, Océanie, Exploration immunologique

    Mots-clés Pascal anglais : Leprosy, Mycobacterial infection, Bacteriosis, Infection, Asymptomatic, Follow up study, Serology, Diagnosis, Antibody, Mycobacterium leprae, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Phenols, Glycolipid, Endemy, Medical screening, Antileprous agent, Antibacterial agent, Epidemiology, Drug combination, Papua New Guinea, Melanesia, Oceania, Immunological investigation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0036459

    Code Inist : 002B05B02L1. Création : 199406.