Important role of hepatitic C virus infection as a cause of chronic liver disease in Somalia.
In a case-control study, 62 Somali patients with chronic liver disease (CLD) including primary hepatocellular carcinoma (HCC) and the same number of age and sex matched controls were investigated for serological markers of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections.
Antibody to HCV (anti-HCV) was detected in 40.3% and 6.5% of cases and controls, respectively.
The corresponding prevalence of hepatitis B surface antigen (HBsAg) were 37.1% and 9.7%, respectively.
Of the HBsAg-positive cases, 34.6% bad antibodies to hepatitis D virus (anti-HD) compared with 14.3% among the HBsAg-positive controls.
Anti-HCV was less prevalent in HBsAg-positive cases than among HBsAg-negative patients (p<0.001), indicating that these agents were independent causes of CLD/HCC.
Mots-clés Pascal : Foie pathologie, Foie, Somalie, Afrique, Hépatome, Virus hépatite C, Flaviviridae, Virus, Facteur risque, Epidémiologie, Virus hépatite B, Hepadnaviridae, Homme, Exploration immunologique, Prévalence, Antigène HBs, Anticorps, Etude cas, Sérum, Appareil digestif pathologie, Tumeur maligne
Mots-clés Pascal anglais : Hepatic disease, Liver, Somali Republic, Africa, Liver cell carcinoma, Hepatitis C virus, Flaviviridae, Virus, Risk factor, Epidemiology, Hepatitis B virus, Hepadnaviridae, Human, Immunological investigation, Prevalence, Hepatitis B surface antigen, Antibody, Case study, Serum, Digestive diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0034888
Code Inist : 002B13C01. Création : 199406.