Phase I of the Trials of Hypertension Prevention was a multicenter, randomized trial of the feasibility and efficacy of seven nonpharmacologic interventions, including sodium reduction, in lowering blood pressure in 30- to 54-year-old individuals with a diastolic blood pressure of 80 to 89 mm Hg.
Six centers tested an intervention designed to reduce dietary sodium to 80 mmol (1800 mg)/24 h with a total of 327 active intervention and 417 control subjects.
The intervention consisted of eight group and two one-to-one meetings during the first 3 months, followed by less-intensive counseling and support for the duration of the study.
The mean net decrease in sodium excretion was 43.9 mmol/24 h at 18 months.
Women had lower sodium intake at baseline and were therefore more likely to decrease to less than 80 mmol/24 h.
Mots-clés Pascal : Hypertension artérielle, Homme, Femelle, Négroïde, Prévention, Etude multicentrique, Efficacité traitement, Faisabilité, Régime alimentaire restrictif, Sodium, Essai clinique, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Hypertension, Human, Female, Negroid, Prevention, Multicenter study, Treatment efficiency, Feasibility, Restricted diet, Sodium, Clinical trial, United States, North America, America, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0026543
Code Inist : 002B12B05B. Création : 199406.