Risk of cancer revealed by follow-up of families with hereditary non-polyposis colorectal cancer : a population-based study.
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by susceptibility to large-bowel cancer, frequently with early onset and localized in the right colon.
Several tumours of other sites may also occur with increased frequency in these families.
During the period 1984-1989, 28 families with HNPCC were identified in our Health Care District through a population-based colorectal cancer registry.
Moreover, 61 additional families were selected and classified as having « suspected » HNPCC.
The objective of the present study is to report the occurrence of new cases of cancer in the 5- to 6-year follow-up of individuals at risk of tumour development in either HNPCC or « suspected » families.
Mots-clés Pascal : Tumeur maligne, Facteur risque, Etude familiale, Prédisposition, Italie, Europe, Epidémiologie, Etude longitudinale, Homme, Maladie héréditaire
Mots-clés Pascal anglais : Malignant tumor, Risk factor, Family study, Predisposition, Italy, Europe, Epidemiology, Follow up study, Human, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 94-0023136
Code Inist : 002B04B. Création : 199406.