Genetic risk and carcinogen exposure : a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer.

Genetic risk and carcinogen exposure : a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer.

Réf. 72609 Article - En anglais

JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 85, n° 14, 1993, pages 1159-1164, 34 réf., ISSN 0027-8874, USA

BELL (D.A.), TAYLOR (J.A.), PAULSON (D.F.), ROBERTSON (C.N.), MOHLER (J.L.), LUCIER (G.W.)

National inst environmental health sci. Lab biochemical risk analysis. Research Triangle Park NC. USA

Background
Numerous studies have associated bladder cancer with exposure to carcinogens present in tobacco smoke and other environmental or occupational exposures.
Approximately 50% of all humans inherit two deleted copies of the GSTM1 gene which encodes for the carcinogen-detoxification enzyme glutathione S-transferase M1.
Recent findings suggest that the GSTM1 gene may modulate the internal dose of environmental carcinogens and thereby affect the risk of developing bladder cancer.
Purpose
We investigated whether the absence of the GSTM1 gene affects bladder cancer risk and whether there are racial differences in GSTM1 genotype frequency.

Mots-clés BDSP : Vessie, Facteur risque, Enzyme, Carcinogène, Tabagisme, Epidémiologie, Etats Unis, Amérique, Homme, Cancer, Appareil urinaire [pathologie]

Mots-clés Pascal : Epithélioma paramalpighien, Vessie urinaire, Facteur risque, Déterminisme génétique, Glutathione transferase, Transferases, Enzyme, Carcinogène, Tabagisme, Génotype, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Vessie pathologie, Voie urinaire pathologie, Appareil urinaire pathologie

Mots-clés Pascal anglais : Transitional cell carcinoma, Urinary bladder, Risk factor, Genetic inheritance, Glutathione transferase, Transferases, Enzyme, Carcinogen, Tobacco smoking, Genotype, Epidemiology, United States, North America, America, Human, Malignant tumor, Bladder disease, Urinary tract disease, Urinary system disease

Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique

Cote : 94-0009060
Code Inist : 002B14C02. Création : 199406.

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