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  1. Genetic risk and carcinogen exposure : a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer.

    Article - En anglais

    Background

    Numerous studies have associated bladder cancer with exposure to carcinogens present in tobacco smoke and other environmental or occupational exposures.

    Approximately 50% of all humans inherit two deleted copies of the GSTM1 gene which encodes for the carcinogen-detoxification enzyme glutathione S-transferase M1.

    Recent findings suggest that the GSTM1 gene may modulate the internal dose of environmental carcinogens and thereby affect the risk of developing bladder cancer.

    Purpose

    We investigated whether the absence of the GSTM1 gene affects bladder cancer risk and whether there are racial differences in GSTM1 genotype frequency.

    Mots-clés Pascal : Epithélioma paramalpighien, Vessie urinaire, Facteur risque, Déterminisme génétique, Glutathione transferase, Transferases, Enzyme, Carcinogène, Tabagisme, Génotype, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Vessie pathologie, Voie urinaire pathologie, Appareil urinaire pathologie

    Mots-clés Pascal anglais : Transitional cell carcinoma, Urinary bladder, Risk factor, Genetic inheritance, Glutathione transferase, Transferases, Enzyme, Carcinogen, Tobacco smoking, Genotype, Epidemiology, United States, North America, America, Human, Malignant tumor, Bladder disease, Urinary tract disease, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0009060

    Code Inist : 002B14C02. Création : 199406.