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  1. Mortality from second tumors among long-term survivors of retinoblastoma.

    Article - En anglais


    Children diagnosed with retinoblastoma, a rare cancer of the eye, tend to develop and die of second primary cancers in childhood and adolescence, but few investigations have followed patients into adulthood.

    Retinoblastoma is frequently caused by inherited mutations of the RB1 tumor suppressor gene.

    Most patients with germline (hereditary) mutations have bilateral disease.


    We sought to quantify the mortality from second malignancies among long-term survivors of retinoblastoma and to identify factors that predispose to these deaths.


    A retrospective cohort study examined mortality among 1603 patients enrolled at 1 year after diagnosis of retinoblastoma during the period 1914-1984.

    Mots-clés Pascal : Rétinoblastome, Survivant, Long terme, Second cancer, Mortalité, Facteur risque, Etude cohorte, Epidémiologie, New York, Etats Unis, Amérique du Nord, Amérique, Massachusetts, Enfant, Homme, Oeil pathologie, Rétinopathie, Système nerveux pathologie, Tumeur maligne, Maladie héréditaire

    Mots-clés Pascal anglais : Retinoblastoma, Survivor, Long term, Second cancer, Mortality, Risk factor, Cohort study, Epidemiology, New York, United States, North America, America, Massachusetts, Child, Human, Eye disease, Retinopathy, Nervous system diseases, Malignant tumor, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 94-0009055

    Code Inist : 002B04B. Création : 199406.