Treatment of serious infections caused by gram-negative bacilli with beta-lactam antimicrobial agents can induce Class I beta-lactamase production.
This phenomenon can result in resistant microorganisms, and has been postulated to be a cause of therapeutic failure.
The charts of patients bacteremic with Pseudomonas aeruginosa, Serralia marcescens, Enterobacter cloacae, Citrobacter freundii, Proteus vulgaris, and Providencia species (n=120) during a 3-year period were reviewed to determine how common the emergence of resistance was, and to determine if in vitro susceptibility testing was a reliable therapeutic guide.
Emergence of resistance was believed to occur when a subsequent bacteremic isolate showed at least a fourfold increase in minimum inhibitory concentration accompanied by a change of interpretive susceptibility category.
Mots-clés Pascal : Infection, Bactériose, Exploration, Traitement, Homme, Exploration microbiologique, Chimiothérapie, Antibiotique, Résistance traitement, Bactérie Gram négatif, bêta-Lactamase, Enzyme, Bactériémie
Mots-clés Pascal anglais : Infection, Bacteriosis, Exploration, Treatment, Human, Microbiological investigation, Chemotherapy, Antibiotic, Negative therapeutic reaction, Gram negative bacteria, bêta-Lactamase, Enzyme, Bacteremia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0679736
Code Inist : 002B02S02. Création : 199406.