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  1. Multiallelic polymorphism of the cartilage collagen gene : no association with osteoarthrosis.

    Article - En anglais

    Objectives-To determine whether any of the type II collagen alleles are associated with generalised osteoarthrosis or osteoarthrosis of the finger joints in the genetically isolated Finnish population.

    Method-Two patient cohorts with evidence for only primary osteoarthrosis and a cohort of healthy control subjects were selected from the Helsinki University Central Hospital and the Rheumatism Foundation Hospital in Finland.

    Forty one patients with primary generalised osteoarthrosis, 49 patients with osteoarthrosis of the finger joints, and 48 control subjects were included.

    Two markers of the type II collagen gene, a PvuII polymorphism and a VNTR polymorphism, were analysed from each subject.

    Mots-clés Pascal : Arthrose, Collagène, Adulte, Homme, Etiopathogénie, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Gène, Allèle, Séquence répétée en tandem, Polymorphisme, Marqueur génétique, Epidémiologie, Finlande, Europe, Génétique, Chromosome C12, Mutation

    Mots-clés Pascal anglais : Osteoarthritis, Collagen, Adult, Human, Etiopathogenesis, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Gene, Allele, Tandemly repeated sequence, Polymorphism, Genetic marker, Epidemiology, Finland, Europe, Genetics, C12-Chromosome, Mutation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0676903

    Code Inist : 002B15E. Création : 199406.