Serum retinol concentrations decrease during illness and thus may not accurately reflect the vitamin A status of populations with a high prevalence of illness.
To quantify the contribution of illness to low serum retinol in a field study of children aged 6-59 mo in northern Ghana, serum retinol values were compared with two indicators of recent illness: symptoms reported by parents and acute-phase protein concentrations in serum.
Serum retinol was not associated with symptoms of illness but showed a significant negative correlation with both alpha1-acid glycoprotein (AGP) and serum amyloid A (SAA).
Elevated AGP was associated with a 24% decrease in mean serum retinol.
A large proportion of asymptomatic children had elevated AGP or SAA concentrations, suggesting that subclinical infections may have had important effects on serum retinol.
Mots-clés Pascal : Malnutrition, Etat nutritionnel, Nourrisson, Homme, Enfant, Marqueur biologique, Morbidité, Rétinol, Ghana, Afrique, Glycoprotéine acide alpha1
Mots-clés Pascal anglais : Malnutrition, Nutritional status, Infant, Human, Child, Biological marker, Morbidity, Retinol, Ghana, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0668926
Code Inist : 002B22C. Création : 199406.