Epidemiologic approaches to assessing the developmental toxicity of lead.
International neurotoxicology conference. Little Rock AR (USA), 1991/10/28.
A variety of designs have been employed in epidemiologic studies of the developmental morbidity associated with low-level lead exposure.
Historically, cross-sectional and retrospective cohort designs have been used most frequently.
Despite improvements in their methodological rigor, however, certain design features constrain the inferences such studies can support.
These limitations stem from the substantial risk that children's exposure status may be misclassified due to reliance on indices with short averaging times, and an inability to identify either age-related changes in vulnerability or time-dependent aspects of the expression of toxicity (e.g., reversibility).
Mots-clés Pascal : Plomb, Métal lourd, Toxicité, Développement postnatal, Développement embryonnaire, Dose faible, Epidémiologie, Enfant, Homme, Prospective, Rétrospective, Système nerveux pathologie
Mots-clés Pascal anglais : Lead, Heavy metal, Toxicity, Postnatal development, Embryonic development, Low dose, Epidemiology, Child, Human, Prospective, Retrospective, Nervous system diseases
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Code Inist : 002B03L05. Création : 199406.