Antecedent clinical features associated with dementia in Parkinson's disease.
In a prospective cohort study, we examined clinical features in 250 nondemented patients with idiopathic Parkinson's disease (PD) and then evaluated their association with incident dementia during 5 years of follow-up.
Seventy-four of the patients became demented.
Odds ratios for incident dementia with PD were increased for the following: being older than 70 years of age (2.7; 1.4 to 5.5), having a PD rating scale score greater than 25 (3.0; 1.5 to 6.2), being depressed (2.7; 1.5 to 6.6), being confused or psychotic on levodopa (3.3; 1.3 to 8.7), or having facial masking as a presenting sign (6.1; 1.4 to 26.9).
Mots-clés Pascal : Parkinson maladie, Démence, Homme, Incidence, Système nerveux pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative, Facteur risque, Système nerveux central pathologie, Epidémiologie, Complication
Mots-clés Pascal anglais : Parkinson disease, Dementia, Human, Incidence, Nervous system diseases, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease, Risk factor, Epidemiology, Complication
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0653645
Code Inist : 002B17G. Création : 199406.