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  1. Activation of blood neutrophils in acute episodes of Farmer's lung.

    Article - En anglais

    Farmer's lung often presents clinically as recurring acute episodes several hours after exposure to moldy hay.

    During these episodes the blood neutrophil count increases.

    Because activated neutrophils release toxic oxygen metabolites and proteinases, we hypothesized that the pulmonary reaction in farmers lung may be induced by the secretory products of activated neutrophils.

    To evaluate this concept, we quantified the respiratory burst of separated blood neutrophils from patients with farmers lung (n=12) during standardized exposure tests with moldy hay.

    The respiratory burst of these cells was evaluated by measuring zymosan-stimulated and lucigenin-amplified chemiluminescence (CL).

    Mots-clés Pascal : Appareil respiratoire pathologie, Immunopathologie, Allergie, Maladie professionnelle, Médecine travail, Exploration, Homme, Neutrophile, Poumon fermier

    Mots-clés Pascal anglais : Respiratory disease, Immunopathology, Allergy, Occupational disease, Occupational medicine, Exploration, Human, Neutrophil, Farmer lung

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0648257

    Code Inist : 002B06C02. Création : 199406.