Activation of blood neutrophils in acute episodes of Farmer's lung.
Farmer's lung often presents clinically as recurring acute episodes several hours after exposure to moldy hay.
During these episodes the blood neutrophil count increases.
Because activated neutrophils release toxic oxygen metabolites and proteinases, we hypothesized that the pulmonary reaction in farmers lung may be induced by the secretory products of activated neutrophils.
To evaluate this concept, we quantified the respiratory burst of separated blood neutrophils from patients with farmers lung (n=12) during standardized exposure tests with moldy hay.
The respiratory burst of these cells was evaluated by measuring zymosan-stimulated and lucigenin-amplified chemiluminescence (CL).
Mots-clés Pascal : Appareil respiratoire pathologie, Immunopathologie, Allergie, Maladie professionnelle, Médecine travail, Exploration, Homme, Neutrophile, Poumon fermier
Mots-clés Pascal anglais : Respiratory disease, Immunopathology, Allergy, Occupational disease, Occupational medicine, Exploration, Human, Neutrophil, Farmer lung
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0648257
Code Inist : 002B06C02. Création : 199406.