With respect to the inverse association of serum ferritin level (SFL) with the risk of gastric cancer (GC) observed in some recent epidemiologic studies, possible mediation by achlorhydria as well as atrophic gastritis (AG), both of which are strongly associated with GC risk at not only the individual but also the population level, was examined in a cross-sectional study of 634 men aged 40 to 49 years randomly selected from 5 populations in Okinawa, Iwate, Nagano, Akita and Tokyo.
AG and achlorhydria were serologically diagnosed based on the criteria of pepsinogen (Pep) I level <70 ng/ml and Pep I/Pep II ratio <3.0, as described previously, and a serum gastrin level of over 140 pg/ml, respectively.
Mots-clés Pascal : Tumeur maligne, Ferritine, Gastrite atrophique, Achlorhydrie, Estomac, Facteur risque, Estomac pathologie, Appareil digestif pathologie, Ferroprotéine, Sérum, Etude transversale, Epidémiologie, Homme, Japon, Asie
Mots-clés Pascal anglais : Malignant tumor, Ferritin, Atrophic gastritis, Achlorhydria, Stomach, Risk factor, Gastric disease, Digestive diseases, Ferroprotein, Serum, Cross sectional study, Epidemiology, Human, Japan, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0644664
Code Inist : 002B13B01. Création : 199406.