Nurses administering aerosolized pentamidine (AP) were studied to determine any effect AP may be having on their health.
Exposure was determined by each nurse's selfreport of treatment given as recorded in a daily log and personal and area pentamidine sampling.
Outcome measures were self-reported symptoms recorded in a daily log and peak expiratory flow rates (PEFR) and cross-shift and cross-week pulmonary function tests (PFTs).
Results revealed no dose-response effect of pentamidine exposure on cross-shift and cross-week PFTs.
However, declines in crossshift PEFRs, diffusion capacities, and increased symptom complaints were observed for a subset of the study population.
This suggested that outcomes were modulated by host factors (history of hay fever and allergy) as well as exposure doses.
Mots-clés Pascal : Immunopathologie, Exploration, Toxicité, Homme, Infirmier, Exposition professionnelle, Pentamidine
Mots-clés Pascal anglais : Immunopathology, Exploration, Toxicity, Human, Nurse, Occupational exposure
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0637899
Code Inist : 002B02U08. Création : 199406.