The clinical efficacy of measles vaccines was investigated in Niakhar, a rural area of Senegal under demographic surveillance in 1987-1990.
Three measles vaccines were tested: a standard Schwarz, a high-titer Edmonston-Zagreb, and a high-titer Schwarz.
The two high-titer vaccines were administered at 5 months of age and the standard Schwarz vaccine at 10 months.
In addition to a formal randomized vaccine trial, data from national campaigns using the standard Schwarz vaccine were also analyzed.
Clinical efficacy was estimated after controlling for exposure.
In the randomized trial, the estimate of the efficacy of the standard Schwarz vaccine was 97.2% (95% confidence interval (Cl) 91.3-98.1).
Mots-clés Pascal : Rougeole, Virose, Infection, Efficacité, Epidémiologie, Vaccination, Etude comparative, Vaccin, Surveillance, Milieu rural, Enfant, Homme, Prévention, Prospective, Sénégal, Afrique
Mots-clés Pascal anglais : Measles, Viral disease, Infection, Efficiency, Epidemiology, Vaccination, Comparative study, Vaccine, Surveillance, Rural environment, Child, Human, Prevention, Prospective, Senegal, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0624627
Code Inist : 002B05C02C. Création : 199406.