Tryptophan contaminants associated with eosinophilia-myalgia syndrome.
Eosinophilia-myalgia syndrome (EMS) has been linked to ingestion of tryptophan contaminated with 1,1'-ethylidenebis[L-tryptophan] (EBT), but other contaminants have received little study.
The authors identified 101 lots of L-tryptophan that had been consumed either by persons with EMS or by asymptomatic tryptophan users and quantified the amounts of EBT and five other contaminants in each lot.
After stratification of case and noncase lots by time of manufacture to adjust for the strong sequential pattern over time among case and noncase lots, higher EBT levels were still associated with a lot's case status, but the association lacked statistical significance (p=0.120, odds ratio=1.56, 95% confidence interval 0.758-3.23).
Mots-clés Pascal : Tryptophane, Eosinophilie, Myalgie, Toxicité, Contamination, Hémopathie, Epidémiologie, Muscle strié pathologie, Douleur, Fabrication, Etats Unis, Amérique du Nord, Amérique, Homme
Mots-clés Pascal anglais : Tryptophan, Eosinophilia, Myalgia, Toxicity, Contamination, Hemopathy, Epidemiology, Striated muscle disease, Pain, Manufacturing, United States, North America, America, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0624624
Code Inist : 002B02U02. Création : 199406.