Influenza vaccines : the effect of vaccine dose on antibody response in primed populations during the ongoing interpandemic period. A review of the literature.
Health authorities tend to favour an increase of the antigen dose in inactivated influenza vaccines from <=10 mug haemagglutinin (HA) per vaccine strain to 15 mug HA/strain.
The increased dose is expected to yield a meaningful increase in the number of subjects to be protected after vaccination.
To verify this expectation, we have reviewed 70 published reports (1978-1991) of serological studies in which anti-HA-IgG antibody after different doses was measures.
In the review, stratification groups of previously primed subjects were formed and the antibody response was estimated for doses of 10 and 15 mug HA by linear k*2-khi2 model.
Mots-clés Pascal : Article synthèse, Homme, Antigène, Hémagglutinine, Vaccination, Evaluation performance, Vaccin, Immunoprotection, Immunité humorale, Souche vaccinale, Influenzavirus A, Influenzavirus, Orthomyxoviridae, Virus, Réponse immune
Mots-clés Pascal anglais : Review, Human, Antigen, Hemagglutinin, Vaccination, Performance evaluation, Vaccine, Immunoprotection, Humoral immunity, Vaccine strain, Influenzavirus A, Influenzavirus, Orthomyxoviridae, Virus, Immune response
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0621926
Code Inist : 002B30A03A. Création : 199406.