An historical cohort study of cardiac catheterization during childhood and the risk of cancer.
This study aimed to determine whether cancer risk was elevated among patients exposed to radiation from diagnostic cardiac catheterization during childhood.
The study cohort included 3915 children who underwent at least one cardiac catheterization at a major children's hospital in Toronto, Canada, between 1950 and 1965, were <=18 years at the time of the procedure, and were residents of Ontario.
Follow-up of the cohort was done by linkage to the Ontario Cancer Registry up to 1986.
A total of seven cancer deaths were observed (0), compared with 5.7 expected (E) based on provincial cancer rates (mortality ratio [O/E]=1.2; 90% confidence interval [CI]:0.6-2.3).
In the analysis of cancer incidence, 13 cancers were detected, compared with 17.3 expected (O/E= 0.75; 90% CI:0.4-1.2).
Mots-clés Pascal : Tumeur maligne, Radiodiagnostic, Cathétérisme, Epidémiologie, Toxicité retardée, Exploration, Rayonnement ionisant, Coeur, Appareil circulatoire pathologie, Canada, Amérique du Nord, Amérique, Mortalité, Incidence, Enfant, Homme, Etude cohorte
Mots-clés Pascal anglais : Malignant tumor, Radiodiagnosis, Catheterization, Epidemiology, Delayed toxicity, Exploration, Ionizing radiation, Heart, Cardiovascular disease, Canada, North America, America, Mortality, Incidence, Child, Human, Cohort study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0601964
Code Inist : 002B04B. Création : 199406.