Theophylline assays performed in a children's hospital were audited, focusing particularly on distribution of plasma concentration values, interpretation of the assay result, appropriateness of the advice conveyed to the physician, and the response to this advice.
Assays performed by a multidisciplinary therapeutic drug monitoring (TDM) service during a 1-month period in 1988 and again in 1992 were chosen for review.
Theophylline concentration in plasma was quantified by fluorescence polarization immunoassay.
Medical technologists interpreted results and made specific recommendations concerning dose changes and/or need for follow-up assays on 48.5 (1988 survey) and 37.9% (1992 survey) of results.
Mots-clés Pascal : Théophylline, Xanthine dérivé, Bronchodilatateur, Antiasthmatique, Asthme, Chimiothérapie, Traitement, Surveillance, Enfant, Homme, Nourrisson, Bronchopneumopathie obstructive, Hôpital, Recommandation, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Theophyllin, Xanthine derivatives, Bronchodilator, Antiasthma agent, Asthma, Chemotherapy, Treatment, Surveillance, Child, Human, Infant, Obstructive pulmonary disease, Hospital, Recommendation, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0589956
Code Inist : 002B02D. Création : 199406.