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  1. Observations on the dose-response curve for arsenic exposure and lung cancer.

    Article - En anglais

    Occupational studies in three countries have related quantitative estimates of arsenic exposure to lung cancer risks.

    Mine exposures in China appear to incur a higher relative risk than arsenic exposures elsewhere.

    All of the studies with quantitative data are consistent with a supralinear dose-response relationship.

    Two studies are also consistent with a linear relationship over an elevated background risk of lung cancer among arsenic-exposed workers.

    Neither toxicokinetic mechanisms nor confounding from age, smoking, or other workplace carcinogens that differ by exposure level appear likely to explain this curvilinearity.

    Mots-clés Pascal : Arsenic, Tumeur maligne, Homme, Métal lourd, Exposition professionnelle, Bronchopulmonaire, Appareil respiratoire pathologie, Epidémiologie, Article synthèse, Suède, Europe, Fonderie, Mine, Méthodologie, Relation dose réponse, Toxicité, Etats Unis, Amérique du Nord, Amérique, Chine, Asie

    Mots-clés Pascal anglais : Arsenic, Malignant tumor, Human, Heavy metal, Occupational exposure, Bronchopulmonary, Respiratory disease, Epidemiology, Review, Sweden, Europe, Foundry, Mine, Methodology, Dose activity relation, Toxicity, United States, North America, America, China, Asia

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0588324

    Code Inist : 002B03L05. Création : 199406.