An inherited variant of the estrogen receptor gene was previously suggested to be a major determinant of a woman's risk of miscarriage.
The authors tested this hypothesis in a case-control study of 29 women who had had two or more miscarriages and 29 women with no miscarriages.
All of the women had given birth in North Carolina between 1987 and 1990.
Estrogen receptor genotype was determined by direct sequencing of DNA.
The gene variant that supposedly produced the risk was found to contain only a silent substitution at codon 87.
Furthermore, instead of an odds ratio of 25 (predicted by the previous study), the odds ratio found was 1.8 (95% confidence interval 0.3-11).
Mots-clés Pascal : Avortement, Epidémiologie, Oestrogène, Homme, Femelle, Gestation pathologie, Variant génétique, Récepteur hormonal, Caroline du Nord, Etats Unis, Amérique du Nord, Amérique, Etude cas témoin
Mots-clés Pascal anglais : Abortion, Epidemiology, Estrogen, Human, Female, Pregnancy disorders, Genetic variant, Hormonal receptor, North Carolina, United States, North America, America, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0588248
Code Inist : 002B20F02. Création : 199406.