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  1. An intelligent and cost-effective computer dosing system for individualizing FK506 therapy in transplantation and autoimmune disorders.

    Article - En anglais

    The accuracy and precision of an intelligent dosing system (IDS) for FK506 in predicting doses to achieve target drug levels has been prospectively evaluated in transplant and autoimmune patients.

    For dose individualization, the knowledge base is updated with patient-specific feedback including the current dose, drug level, and the new target level.

    The study population of 247 patients consisted of 97 transplant patients (fiver and kidney) and 50 patients with autoimmune disorders.

    Patients in the transplant study group were entered sequentially and followed as a cohort.

    Mots-clés Pascal : Immunodépresseur, Chimiothérapie, Traitement, Dose efficace, Rein, Foie, Transplantation, Maladie autoimmune, Posologie, Système informatique, Intelligence artificielle, Ordinateur, Homme, Analyse avantage coût, Economie santé, Appareil urinaire pathologie, Appareil digestif pathologie, FK 506

    Mots-clés Pascal anglais : Immunosuppressive agent, Chemotherapy, Treatment, Effective dose, Kidney, Liver, Transplantation, Autoimmune disease, Posology, Computer system, Artificial intelligence, Computer, Human, Cost benefit analysis, Health economy, Urinary system disease, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0580105

    Code Inist : 002B02Q. Création : 199406.