Overnight urine samples were collected from approximately 60 male adults in each of 69 counties of China in 1989.
Two specimens were collected from each subject-one after a loading dose of proline and ascorbic acid and another after a loading dose of proline only.
Levels of N-nitrosamino acids and nitrate were measured in urine samples and correlated with cumulative mortality rates for subjects aged between 0 and 64 years in the 1970s.
Oesophageal cancer mortality rates were positively and significantly associated with (i) urinary levels of excreted N-nitrosoproline (NPRO) (after proline and ascorbic acid loading or proline loading only), (ii) N-nitrososarcosine levels, and (iii) nitrosation potential (the decrease in the amount of urinary NPRO after adding ascorbic acid to the proline load).
Mots-clés Pascal : Tumeur maligne, Composé nitroso, Mortalité, Oesophage, Oesophage pathologie, Appareil digestif pathologie, Urine, Carcinogenèse, Etiologie, Epidémiologie, Chine, Asie, Homme
Mots-clés Pascal anglais : Malignant tumor, Nitroso compound, Mortality, Esophagus, Esophageal disease, Digestive diseases, Urine, Carcinogenesis, Etiology, Epidemiology, China, Asia, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0577028
Code Inist : 002B13A01. Création : 199406.