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  1. Geographic association between urinary excretion of N-nitroso compounds and oesophageal cancer mortality in China.

    Article - En anglais

    Overnight urine samples were collected from approximately 60 male adults in each of 69 counties of China in 1989.

    Two specimens were collected from each subject-one after a loading dose of proline and ascorbic acid and another after a loading dose of proline only.

    Levels of N-nitrosamino acids and nitrate were measured in urine samples and correlated with cumulative mortality rates for subjects aged between 0 and 64 years in the 1970s.

    Oesophageal cancer mortality rates were positively and significantly associated with (i) urinary levels of excreted N-nitrosoproline (NPRO) (after proline and ascorbic acid loading or proline loading only), (ii) N-nitrososarcosine levels, and (iii) nitrosation potential (the decrease in the amount of urinary NPRO after adding ascorbic acid to the proline load).

    Mots-clés Pascal : Tumeur maligne, Composé nitroso, Mortalité, Oesophage, Oesophage pathologie, Appareil digestif pathologie, Urine, Carcinogenèse, Etiologie, Epidémiologie, Chine, Asie, Homme

    Mots-clés Pascal anglais : Malignant tumor, Nitroso compound, Mortality, Esophagus, Esophageal disease, Digestive diseases, Urine, Carcinogenesis, Etiology, Epidemiology, China, Asia, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0577028

    Code Inist : 002B13A01. Création : 199406.