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  1. The activity of piperacillin/tazobactam against clinical isolates collected in 20 UK centres and the design of a disc test for susceptibility testing.

    Article - En anglais

    The in-vitro activities of piperacillin plus tazobactam at ratios of 4: 1, 8: 1 and 16: 1 were determined against 952 non-copy clinical aerobic bacterial isolates collected from 20 UK centres.

    Tazobactam enhanced the activity of piperacillin against Enterobacteriaceae, Staphylococcus aureus, Haemophilus influenzae and Moraxella catarrhalis.

    No enhancement was noted for Pseudomonas aeruginosa, other Pseudomonas spp., streptococci and enterococci.

    For 95-6% of strains MICs were either the same or only one two-fold dilution different with all the three ratios of tazobactam, and for most of the remaining strains the piperacillin MIC was lowest with the highest proportion of tazobactam (4:1).

    The percentage of strains which remained resistant was also lowest with the 4:1 ratio.

    Mots-clés Pascal : Pipéracilline, Tazobactam, Association médicamenteuse, Test sensibilité médicamenteuse, Enterobacteriaceae, Bactérie, Staphylococcus aureus, Micrococcaceae, Micrococcales, Haemophilus influenzae, Pasteurellaceae, Pseudomonas, Pseudomonadaceae, Pseudomonadales, Moraxella, Neisseriaceae, Streptococcus, Streptococcaceae, In vitro, Isolat clinique, Homme, Antibiotique, Antibactérien, Pénicilline dérivé, Inhibiteur enzyme, bêta-Lactamase, Enzyme, Royaume Uni, Europe

    Mots-clés Pascal anglais : Drug combination, Drug susceptibility test, Enterobacteriaceae, Bacteria, Staphylococcus aureus, Micrococcaceae, Micrococcales, Haemophilus influenzae, Pasteurellaceae, Pseudomonas, Pseudomonadaceae, Pseudomonadales, Moraxella, Neisseriaceae, Streptococcus, Streptococcaceae, In vitro, Clinical isolate, Human, Antibiotic, Antibacterial agent, Penicillin derivatives, Enzyme inhibitor, bêta-Lactamase, Enzyme, United Kingdom, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0570274

    Code Inist : 002B02S02. Création : 199406.