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  1. Prevalence of pyruvate kinase deficiency among the Chinese : determination by the quantitative assay.

    Article - En anglais

    The prevalence of pyruvate kinase (PK) deficiency among the Chinese population has not been established.

    Fung et al. (Arch Dis Child 44:373-376, 1969) and Wu et al. (Am J Hemafol 20:139-144, 1985) indicate 3.4% and 2.1% PK deficiency prevalence rates, respectively, the higher figure based on Beutler's screening test [3] without confirmatory testing.

    Neither figure is consistent with the occurrence of hemolytic anemia from this cause in the experiences of hematologists in Hong Kong.

    Using the standard quantitative assay, we measured PK activity in blood samples from 1,100 local Chinese people.

    The assay was automated on a centrifugal analyser, and the results were expressed in IU per gram of hemoglobin (IU/g Hb).

    Mots-clés Pascal : Déficit, Chinois, Pyruvate kinase, Enzyme, Prévalence, Anémie hémolytique, Enzymopathie, Métabolisme pathologie, HongKong, Asie, Epidémiologie, Analyse quantitative, Homme

    Mots-clés Pascal anglais : Deficiency, Chinese, Pyruvate kinase, Enzyme, Prevalence, Hemolytic anemia, Enzymopathy, Metabolic diseases, Hong Kong, Asia, Epidemiology, Quantitative analysis, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0553519

    Code Inist : 002B19A01. Création : 199406.