Cautions in the use of antecedents as surrogates for confounders.
When lacking information on confounding variables, epidemiologists have used surrogates which are antecedents of both the exposures and confounders of interest.
The usefulness of this strategy is explored in a series of scenarios for a prospective epidemiologic study wherein risk ratios relating antecedent to confounder, antecedent to exposure, and confounder to exposure were varied.
Antecedent-adjusted, confounder-adjusted, and crude risk ratios were calculated and compared.
The antecedent-adjusted risk ratio was useful, that is, was closer to the confounder-adjusted risk ratio than was the crude risk ratio, in 1,067 (49%) of 2,187 scenarios.
Mots-clés Pascal : Epidémiologie, Méthodologie, Prospective
Mots-clés Pascal anglais : Epidemiology, Methodology, Prospective
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0549341
Code Inist : 002B30A01A1. Création : 199406.