Population and familial relative risks of disease associated with environmental factors in the presence of gene-environment interaction.
With increasing availability of polymorphic DNA markers, family studies can be used to identify linked susceptibility genes for chronic diseases.
Nevertheless, in the presence of gene-environment interaction, the ability of family studies to detect associations between exposures and diseases has not been adequately compared with population studies.
The authors derive and compare exposure relative risk measures obtained from population studies with those obtained from studying siblings of affected individuals.
For multiplicative joint effects on disease risk between the gene and the exposure, it can be shown that exposure relative risks in siblings are identical to those obtained from the population.
Mots-clés Pascal : Epidémiologie, Etude familiale, Méthodologie, Déterminisme génétique, Facteur risque, Homme, Marqueur génétique, Facteur milieu, Modèle statistique, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Epidemiology, Family study, Methodology, Inheritance, Risk factor, Human, Genetic marker, Environmental factor, Statistical model, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0549339
Code Inist : 002B30A01A1. Création : 199406.