Markers of prognosis in breast cancer : the relationship between binding of the lectin HPA and histological grade, SPF, and ploidy.
Abnormal cellular glycosylation as demonstrated by the binding of a lectin from Helix pomatia (HPA) to paraffin-embedded sections has been shown in several studies to be associated with aggressive biological behaviour and poor long-term patient prognosis in breast cancer.
This study aims to address the possibility that expression of the HPA binding ligand may be of prognostic significance through an association with increased cellular proliferation (as measured by S-phase fraction and histological grade), anaplasia (reflected in histological grade), or ploidy (DNA index).
In a 24 year retrospective study, paraffin-embedded sections of 366 primary breast cancers were stained for binding of HPA.
All tumours were assessed for histological grade.
Mots-clés Pascal : Marqueur tumoral, Pronostic, Glycosylation, Fixation biologique, Femelle, Lectine, Helix pomatia, Gastropoda, Mollusca, Invertebrata, Ploïdie, Grade histologique, Cytométrie flux, Rétrospective, Epidémiologie, Royaume Uni, Europe, Homme, Tumeur maligne, Glande mammaire, Glande mammaire pathologie
Mots-clés Pascal anglais : Tumoral marker, Prognosis, Glycosylation, Biological fixation, Female, Lectin, Helix pomatia, Gastropoda, Mollusca, Invertebrata, Ploidy, Histological grading, Flow cytometry, Retrospective, Epidemiology, United Kingdom, Europe, Human, Malignant tumor, Mammary gland, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0546592
Code Inist : 002B20E02. Création : 199406.