The prognostic effect of histological tumor grade was evaluated in 1036 patients with early breast cancer (pT1 pNO M0) entered into a trial comparing mastectomy and breast preserving treatment.
All analyses were adjusted for the factors treatment, patients'age, and tumor size.
Tumor grade was defined according to Bloom and Richardson based on the sum of scores assigned to each of three histological features: 1) degree of differentiation, 2) pleomorphism, and 3) mitotic index.
The relative importance of these factors with regard to disease-free survival was evaluated.
In univariate as well as in multivariate analyses the pleomorphism was the only factor showing a significant effect (univariate: p=0.0024, multivariate: p=0.015).
Mots-clés Pascal : Pronostic, Grade histologique, Nodule, Facteur risque, Homme, Femelle, Epidémiologie, Allemagne, Europe, Analyse statistique, Modèle Cox, Tumeur maligne, Glande mammaire, Glande mammaire pathologie, Pléomorphisme
Mots-clés Pascal anglais : Prognosis, Histological grading, Nodule, Risk factor, Human, Female, Epidemiology, Germany, Europe, Statistical analysis, Cox model, Malignant tumor, Mammary gland, Mammary gland diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0546591
Code Inist : 002B20E02. Création : 199406.