Multiple clinical and biological autoimmune manifestations in 50 workers after occupational exposure to silica.
Objectives-A self referred group of four workers from a factory producing scouring powder with a high silica content showed a surprisingly high number of features compatible with a connective tissue disease.
Further subjects working at the same factory were subsequently studied to evaluate the relation between this exposure and the development of autoimmune processes.
Methods-A total of 50 subjects (44 women, six men; mean (SD) age 43.7 (5.5) years; mean duration of employment 6.1 years) underwent a prospective study including clinical history and physical examination, an immnobiological study, HLA typing, radiological and functional oesophageal and respiratory examination, ophthalmological examination, and isotopic testing of salivary glands.
Mots-clés Pascal : Maladie autoimmune, Facteur risque, Adulte, Homme, Epidémiologie, Maladie système, Médecine travail, Elément minéral, Silice, Exposition professionnelle, Symptomatologie, Etude statistique
Mots-clés Pascal anglais : Autoimmune disease, Risk factor, Adult, Human, Epidemiology, Systemic disease, Occupational medicine, Inorganic element, Silica, Occupational exposure, Symptomatology, Statistical study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0545332
Code Inist : 002B30B01A. Création : 199406.