logo BDSP

Base documentaire

  1. Who is ordering all those cyclosporin concentrations and how do they use them ? An audit of cyclosporin therapeutic durg monitoring.

    Article - En anglais

    Therapeutic drug monitoring is used for the immunosuppressant drug, cyclosporin, even though it is often unclear what concentration should be targetted.

    At St.

    Vincent's Hospital, Sydney, a polyclonal, whole blood immunoassay is used to measure cyclosporin and metabolites.

    The objective of the present study was to audit how the concentration results produced by the laboratory were actually used to adjust dosage.

    Each transplantation unit was asked about their policy for dosage adjustment and which therapeutic range was used.

    The audit criteria were considered to be passed if the action taken based on a concentration result was (a) predictable based solely on the concentration and its relationship to the stated therapeutic range (e.g., dosage increased if concentration was below therapeutic range) or (b) based on clinical consideration.

    (e.g., dosage decreased because of increased serum creatinine).

    Mots-clés Pascal : Ciclosporine, Immunodépresseur, Pharmacovigilance, Homme, Organe, Chirurgie, Homotransplantation, Epidémiologie, Milieu hospitalier, Métabolite, Métabolisme, Pharmacocinétique, Optimisation, Posologie, Australie, Océanie

    Mots-clés Pascal anglais : Immunosuppressive agent, Drug monitoring, Human, Organ, Surgery, Homotransplantation, Epidemiology, Hospital environment, Metabolite, Metabolism, Pharmacokinetics, Optimization, Posology, Australia, Oceania

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0544442

    Code Inist : 002B02Q. Création : 199406.