Correlates of the rate of decline of CD4+ lymphocytes among injection drug users infected with the human immunodeficiency virus.
Changes in the level of CD4-bearing T-lymphocytes in injection drug users infected with the human immunodeficiency virus were evaluated in a sample of 318 subjects enrolled from a methadone program in the Bronx, New York, from 1985 through 1989.
Follow-up continued through 1990.
The percentage of CD4+ T-lymphocytes (CD4%) was used to maximize the stability of measurements.
The rate of decline of the CD4% was determined using a random-effects assumption, and predictors of rate of decline were evaluated using an autoregressive model.
The rate of CD4% decline was approximately 1.2 CD4% lost per 6 months, with a higher rate in recent seroconverters (2.2 CD4% lost).
Mots-clés Pascal : Immunodéficit acquis syndrome, Virose, Infection, Toxicomanie, Homme, Immunopathologie, Hémopathie, Voie intraveineuse, Lymphocyte T, Epidémiologie, New York, Etats Unis, Amérique du Nord, Amérique, Antigène CD4, Etude longitudinale, Exploration immunologique
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Drug addiction, Human, Immunopathology, Hemopathy, Intravenous administration, T-Lymphocyte, Epidemiology, New York, United States, North America, America, Follow up study, Immunological investigation
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0538219
Code Inist : 002B06D01. Création : 199406.